中文名稱: 環(huán)吡酮胺
中文同義詞: 環(huán)吡酮;環(huán)匹羅司;6-環(huán)己基-1-羥基-4-甲基-2(1H)-吡啶酮;環(huán)吡司胺;環(huán)吡酮胺;環(huán)己吡酮氨;6-環(huán)己基-1-羥基-4-甲基-2(IH)-吡啶酮;環(huán)吡司
英文名稱: Ciclopirox
英文同義詞: 6-CYCLOHEXYL-1-HYDROXY-4-METHYL-1H-PYRIDIN-2-ONE;CICLOPIROX;CIELOPIROX;6-Cyclohexyl-1-hydroxy-4-methyl-2[1H]-pyridinone;6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone;Brumixol;Ciciopirox;Cidochem
CAS號: 29342-05-0
分子式: C12H17NO2
分子量: 207.27
EINECS號: 249-577-2
相關(guān)類別: Intermediates & Fine Chemicals;Pharmaceuticals;抗病源性微生物藥;抗真菌感染藥物;藥物;Heterocycles;原料藥
原料藥 > 人工合成抗感染類藥 > 抗真菌類藥 > 環(huán)吡酮胺
外用抗真菌藥 環(huán)吡酮胺是一種新型廣譜外用抗真菌藥，由聯(lián)邦德國藥廠研制成功，作用機(jī)制是通過改變真菌細(xì)胞膜的完整性，引起細(xì)胞內(nèi)物質(zhì)外流，并阻斷蛋白質(zhì)前體物質(zhì)的攝取，導(dǎo)致真菌細(xì)胞死亡，對皮膚癬菌、酵母菌、霉菌等具有較強(qiáng)的抑菌和殺菌作用，滲透性強(qiáng)。在較高濃度還可以對各種放線菌、革蘭陽性和革蘭陰性菌及支原體、衣原體、毛滴蟲、陰道滴蟲和綠膿桿菌等也有一定抑制作用。
與咪唑類抗真菌藥相比，環(huán)吡酮胺對皮膚真菌賴以生存的角質(zhì)層有極強(qiáng)的滲透力，故對角質(zhì)層深部真菌，如甲癬等有顯著的抑菌。
含量：99%
質(zhì)量標(biāo)準(zhǔn)：usp35
是否現(xiàn)貨：現(xiàn)貨庫存款到發(fā)貨.
包裝：1kg鋁箔袋 5kg紙板桶
1、 Discriminate      鑒別      紅外光吸收圖譜應(yīng)與對照品圖譜一致       IR absorption Conforms to standard符合規(guī)定 Complies
2、 Description     性  狀           白色結(jié)晶性粉末         White crystalline powder符合規(guī)定 Complies
3 Ciclopirox Olamine  content      環(huán)吡酮胺含量97.5～101.5%99.55%
4. Ethanolamine content 2-氨基含量223~230mg/g225mg/g
5、Residue on ignition     灼燒殘?jiān)?≤0.1%0.05%
6、 Losson drying     干燥失重≤1.5%0.36%
7、  PH值8．0-9.08.4
8、heavy metal content a     重金屬含量≤10ppm符合 Conform
9 Related aubstances     相關(guān)物質(zhì)雜質(zhì)A<0.5% 總雜質(zhì)<0.5% 單雜質(zhì)<0.1% impuritiyA<0.5%    Theimpurities<0.5%    any impurities<0.1%符合 Conform
10、溶解度 Solubilyty易溶于醇與等有機(jī)溶劑，微溶于水 Soluble in alcohol and organic solvents such as  dichloromethane and slightly in water符合 Conform
11、殘留溶劑 ＜600ppm   dichloromethane＜600ppm 甲 ＜890ppm  toluene＜890ppm 乙酯＜5000ppm  ethyl＜5000ppm＜250ppm dichloromethane＜250ppm 甲 ＜280ppm toluene＜280ppm 乙酯＜1200ppm  ethyl＜1200ppm


Chinese name: ciclopirox 
Chinese Synonyms: Ciclopirox; ring cefpirome Division; 6-cyclohexyl-1-hydroxy-4-methyl -2 (1H) - pyridone; ciclopirox amine; ciclopiroxolamine; cyclohexanone povidone ammonia ethanol ; 6-cyclohexyl-1-hydroxy-4-methyl -2 (IH) - pyridinone; ciclopirox 
English name: Ciclopirox 
English Synonyms: 6-CYCLOHEXYL-1-HYDROXY-4-METHYL-1H-PYRIDIN-2-ONE; CICLOPIROX; CIELOPIROX; 6-Cyclohexyl-1-hydroxy-4-methyl-2 [1H] -pyridinone; 6-Cyclohexyl- 1-hydroxy-4-methyl-2 (1H) -pyridone; Brumixol; Ciciopirox; Cidochem 
CAS: 29342-05-0 
Formula: C12H17NO2 
Molecular Weight: 207.27 
EINECS: 249-577-2 
Related Categories: Intermediates & Fine Chemicals; Pharmaceuticals; endogenous microbial drug resistance; anti-fungal infection drug; drugs; Heterocycles; API 
API> synthetic anti-infective drugs> Antifungal> ciclopirox 
Ciclopirox topical antifungal agents is a novel broad-spectrum topical antifungal agents, Federal Republic of Germany by pharmaceutical companies successfully developed the mechanism by changing the integrity of the fungal cell membrane, causing the outflow of intracellular material, and blocking the protein body before ingested substances, resulting in fungal cell death, against dermatophytes, yeasts, molds, and so has a strong bactericidal effect, strong permeability. At higher concentrations can also be a variety of actinomycetes, Gram-positive and Gram-negative bacteria and mycoplasma, chlamydia, trichomoniasis, vaginal trichomoniasis and Pseudomonas aeruginosa also have a certain effect. 
Compared with the imidazole antifungal, ciclopirox survival of skin fungus has a strong penetration of the stratum corneum, so the cuticle deep fungi, such as onychomycosis, a significant inhibition. 
Content: 99% 
Quality Standard: usp33 
Packaging: 1kg aluminum foil bag 5kg cardboard